Inter Milan, who were without Mauro Icardi, eased past Rapid Wien to clinch a last 16 berth in the UEFA Europa League, while Chelsea thrashed Malmo at Stamford Bridge.
Inter Milan 4-0 Rapid Wien
Inter Milan secured their name in the hat for the round of 16 draw on Friday after defeating Rapid Wien 4-0 in their second-leg tie.
Star forward Mauro Icardi was left out of the squad as Lautaro Martínez led the attack for the second successive game.
The hosts raced into a two-goal lead in the opening 20 minutes thanks to strikes from Matias Vecino and Andrea Ranocchia.
The Serie A outfit managed to bag a third goal in the final 10 minutes of the second half through Ivan Perisic while Matteo Politano rounded off the scoring to make it 5-0 on aggregate.
Chelsea 3-0 Malmo
Chelsea advanced to the last 16 with a 5-1 aggregate win over Swedish outfit Malmo.
The Blues entered the encounter with a slight advantage following 2-1 first-leg win last week.
However, Chelsea put some daylight between themselves and Malmo when Olivier Giroud netted from close range on 56 minutes.
After Malmo had Rasmus Bengtsson sent off in the 73rd minute, Ross Barkley sealed the win with a well-taken free-kick two minutes later.
Callum Hudson-Odoi rounded off the scoring for Chelsea with a neat finish from close range as the Blues join fellow Premier League outfit Arsenal in the next round.
Genk 1-4 Slavia Praha
Slavia Praha put on an impressive performance on the road to secure their spot in the last 16.
After a scoreless first leg, Leandro Trossard gave Genk the lead in the 10th minute before Vladimír Coufal restored parity for the away side.
Ibrahim Traore then put Slavia ahead in the 53rd minute while Milan Skoda netted a quick-fire brace to put the visitors 4-1 ahead with 20 minutes remaining.
Bayer Leverkusen 1-1 Krasnodar
Bayer Leverkusen crashed out of the competition after only managing a 1-1 draw at the BayArena.
After playing to a goalless first leg, it was Krasnodar who broke the deadlock after 84 minutes thanks to a strike from Magomed Suleymanov.
Charles Aránguiz pulled one back for Leverkusen four minutes later, but Krasnodar held on for the draw and advanced on the away goals rule.
Real Betis 1-3 Rennes
Rennes advanced to the next round after thumping Real Betsi 3-1 in the second leg to claim a 6-4 aggregate triumph.
The hosts were left stunned in the first half as Rennes went 2-0 up through Ramy Bensebaini and Adrien Hunou.
Giovani Lo Celso pulled a goal back for Betis just before the halftime break, however Mbaye Niang got Rennes’ in the fourth minute of second-half stoppage time.
Dynamo Kiev 1-0 Olympiakos
Ukraine outfit Dynamo Kiev sent Olympiakos crashing out of Europe with a 3-2 aggregate win.
The first leg encounter ended 2-2 in Greece, but Kiev got the game’s only goal in the second leg after 32 minutes thanks to a strike from Fran Sol fired.
Benfica 0-0 Galatasaray
Despite playing to a goalless draw with Galatasaray on Thursday evening, Benfica secured their spot in the last 16 after the winning the tie 2-1 on aggregate. Kickoff